• Contract
  • Cape Town, Western Cape, Rondebosch, 7700 View on Map
  • University of Cape Town posted 3 weeks ago
  • Posted : Aug 26, 2021 -Accepting applications
  • Salary: R638,396.00 - R751,052.00 / Annual
  • View(s) 108

Job Detail

  • Offered Salary The annual cost of employment, including benefits, is between R638 396 and R751 052.
  • Qualifications phd
  • Industry Research, science & technology
  • Reference E210305
  • Centre UCT
  • Enquiries
    Dr Mathew Njoroge: [email protected]
  • Where to submit application
    To apply, please e-mail the below documents in a single pdf file to Ms Natasha Khan at [email protected] . - UCT Application Form (download at - Cover letter stating your suitability for the role - Curriculum Vitae (CV) Please ensure the title and reference number are indicated in the subject line.
  • Notes
    An application which does not comply with the above requirements will be regarded as incomplete. Only shortlisted candidates will be contacted and may be required to undergo a competency test.

Job Description

The Drug Discovery and Development Centre (H3D) is an interdisciplinary, soft-funded research unit at the University of Cape Town. H3D staff and laboratories are situated across three sites on the UCT campus. H3D is seeking to appoint a Senior Investigator on a 3-year contract, starting on 1st September 2021 or as soon as possible thereafter. This position will be predominantly laboratory-based with the main purpose in taking a leading role in the design and conduct of drug metabolism and pharmacokinetics (DMPK) and bioanalysis assays for the progression of compounds through the drug discovery cascade. Requirements: PhD in an appropriate discipline (chemistry, analytical chemistry or biological sciences) or equivalent qualification. 4 years industrial or academic experience in a drug discovery, bioanalysis, or related research laboratory. Publications in DMPK, bioanalysis, and/or medicinal chemistry in peer reviewed international journals with major contributions to DMPK, bioanalysis or pharmacometric modelling aspects. Strong bench experience in DMPK experiments and/or LC-MS analysis Advantages: Experience in a cross-disciplinary drug discovery team either in a university setting or at a pharmaceutical/biotech company.Hands-on experience in the use and maintenance of AB Sciex and/or Agilent LC-MS systems. Demonstrated competence in working with cellular biology assays or animal models of PK/efficacy. Demonstrated experience with pharmacometric modelling, human pharmacokinetics or human dose prediction. Experience working in a matrix-based organizational structure. Responsibilities will include, but are not limited to the following: Design, conduct and oversee DMPK and bioanalysis studies within a team setting with the goal of identifying pre-clinical drug candidates. Participate and present work in project meetings and write research reports. Supervise junior team members and postdocs. Comply with standard operating procedures for laboratory safety, use of instruments and data management

Required skills

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